Development of a Safe Continuous Process to NaNT via Solid Phase "Catch and Release"
- emiliefarrugia315
- Jul 14, 2021
- 1 min read
Sodium nitrotetrazolate (NaNT) is a key intermediate to copper(I) nitrotetrazolate (DBX-1), a material of interest as a replacement for lead based primary explosives. Historical syntheses of NaNT were plagued with safety issues that prevented the large-scale manufacturing of NaNT. In this article, we detail the development of a safe process to generate NaNT in a continuous flow reactor via solid phase “catch and release”; a process that also reduces the formation of the most detrimental impurities that inhibit the synthesis of DBX-1. Furthermore, we discuss the demonstration of this process in 100 and 1000 mL continuous stirred tank reactors (CSTRs) and implications of scale-up of this process for robust production of NaNT at the manufacturing scale.
Read the full paper here.

Recent Posts
See AllWe are excited to share that our President, David am Ende, recently published the second edition of his textbook ‘Chemical Engineering in...
Chemical Engineering in the Pharmaceutical Industry: Active Pharmaceutical Ingredients, 2nd Edition, Eds. D.J. am Ende and M.T. am Ende,...
M.T. am Ende, W. Ketterhagen, A. Prpich, P. Doshi, S. García-Muñoz, and R. Bharadwajh, “Drug Product Process Modeling” in Chemical...
Comments